Opportunity Information: Apply for RFA PS 23 002
The grant opportunity titled "Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)" (Funding Opportunity Number RFA PS 23 002) is a Centers for Disease Control and Prevention (CDC) cooperative agreement designed to strengthen evidence around telehealth-based HIV care and prevention. The core aim is to evaluate an enhanced telehealth program that supports people in staying engaged in care and consistently taking HIV-related medications, while also examining how practical it is to integrate these telehealth strategies into routine clinical workflows over time. In other words, the project is not only about whether telehealth works, but also about what it takes to make it work reliably in real-world healthcare settings.
The program places strong emphasis on a hybrid effectiveness-implementation research approach, meaning the awardee is expected to study clinical outcomes and real-world delivery factors at the same time. On the effectiveness side, the work focuses on two related groups: clinically stable people with HIV who are on antiretroviral therapy (ART), and people at risk for HIV infection who are using pre-exposure prophylaxis (PrEP). For people with HIV, the intent is to determine whether an enhanced telehealth model helps maintain medication adherence and ongoing engagement in care. For PrEP users, the intent is to assess whether telehealth helps support adherence to PrEP as a prevention tool. On the implementation side, the awardee must identify barriers and facilitators that affect delivery, such as staffing, patient experience, technology access, clinical processes, and other operational issues that determine whether the approach can be sustained and scaled.
A major required component is an economic evaluation. The recipient is expected to assess the costs and cost-effectiveness of delivering telehealth services for patients using ART or PrEP. This includes looking beyond basic program expenses and considering whether the enhanced telehealth model provides good value relative to outcomes such as improved adherence, better retention in care, or more consistent use of prevention medication. The funding description also highlights specific telehealth enhancements that can be evaluated, which may include multi-month prescription refills to reduce pharmacy and clinic visit burden, biospecimen self-collection to support remote monitoring or laboratory needs, and the use of specialized staff roles such as community health workers and patient navigators to help patients overcome logistical, social, or system-level barriers.
The opportunity is explicitly focused on populations disproportionately affected by HIV or at elevated risk of acquisition, reflecting equity-centered public health priorities. The NOFO calls out cisgender Black women with HIV, transgender women, and gay, bisexual, and other men who have sex with men (MSM) as priority populations for the enhanced telehealth model. This emphasis signals that applicants should be prepared to design and evaluate telehealth strategies that are responsive to the realities these groups face, including access barriers, stigma, structural inequities, and challenges with continuity of care, while still producing measurable adherence, retention, and implementation outcomes.
Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism, which typically means the CDC expects substantial involvement during the project period (for example, collaboration on evaluation approaches, performance monitoring, or dissemination). The Assistance Listing (CFDA) number is 93.084, and eligible applicants are broad, spanning state, county, and city governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofit organizations (with or without 501(c)(3) status); and for-profit organizations, including small businesses. The NOFO was created on January 10, 2023, with an application deadline of March 17, 2023 (applications due by 11:59 pm ET). The award ceiling is $450,000, and the CDC anticipated making two awards, indicating a competitive process with limited slots and a clear expectation of rigorous evaluation design and strong implementation planning.
Taken together, the grant supports projects that can generate practical, actionable evidence on how enhanced telehealth models can keep people adherent to ART and PrEP and retained in care, while also documenting the real-world conditions needed for successful adoption. The ideal project under this NOFO would show measurable adherence and retention outcomes, provide a clear picture of implementation challenges and enablers, and produce cost and cost-effectiveness findings that help health systems and public health programs decide how to deploy telehealth enhancements in a sustainable way, especially for communities most impacted by HIV.Apply for RFA PS 23 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Jan 10, 2023.
- Applicants must submit their applications by Mar 17, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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Frequently Asked Questions (FAQs)
1) What is the title of this grant opportunity?
The opportunity is titled "Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)."
2) What is the Funding Opportunity Number (NOFO number)?
The Funding Opportunity Number is RFA PS 23 002.
3) Which federal agency is offering this funding?
This is a Centers for Disease Control and Prevention (CDC) funding opportunity.
4) What type of funding mechanism is this?
This is a cooperative agreement. That typically indicates substantial CDC involvement during the project period, such as collaboration on evaluation approaches, performance monitoring, and/or dissemination.
5) What is the Assistance Listing (CFDA) number?
The Assistance Listing (CFDA) number is 93.084.
6) What is the overall purpose of the grant?
The purpose is to strengthen evidence around telehealth-based HIV care and prevention by evaluating an enhanced telehealth program that supports (1) retention in care and (2) adherence to HIV-related medications, while also examining how feasible it is to integrate these telehealth strategies into routine clinical workflows over time.
7) Is this grant only about whether telehealth works?
No. The project is designed to assess both effectiveness (whether telehealth improves key outcomes) and implementation (what it takes to make the model work reliably and sustainably in real-world healthcare settings).
8) What research approach does the NOFO emphasize?
The NOFO emphasizes a hybrid effectiveness-implementation research approach, meaning the awardee is expected to study clinical outcomes and real-world delivery factors at the same time.
9) Which patient or participant groups are the focus of the evaluation?
The evaluation focuses on two related groups:
- Clinically stable people with HIV who are on antiretroviral therapy (ART)
- People at risk for HIV infection who are using pre-exposure prophylaxis (PrEP)
10) What outcomes are expected on the effectiveness side for people with HIV on ART?
For clinically stable people with HIV on ART, the intent is to determine whether an enhanced telehealth model helps maintain medication adherence and ongoing engagement in care (retention).
11) What outcomes are expected on the effectiveness side for people using PrEP?
For people using PrEP, the intent is to assess whether telehealth helps support adherence to PrEP as an HIV prevention tool.
12) What does the implementation side of the project need to examine?
The awardee must identify barriers and facilitators that affect real-world delivery and sustainability. Examples called out include staffing, patient experience, technology access, clinical processes, and other operational issues that determine whether the approach can be sustained and scaled.
13) Is an economic evaluation required?
Yes. A major required component is an economic evaluation assessing costs and cost-effectiveness of delivering telehealth services for patients using ART or PrEP.
14) What does the economic evaluation need to consider?
The economic evaluation is expected to look beyond basic program expenses and consider whether the enhanced telehealth model provides good value relative to outcomes such as improved adherence, better retention in care, or more consistent use of prevention medication.
15) What types of telehealth enhancements may be evaluated under this opportunity?
The funding description highlights telehealth enhancements that can be evaluated, which may include:
- Multi-month prescription refills to reduce pharmacy and clinic visit burden
- Biospecimen self-collection to support remote monitoring or laboratory needs
- Specialized staff roles such as community health workers and patient navigators to help address logistical, social, or system-level barriers
16) Does the opportunity emphasize any specific populations?
Yes. The opportunity explicitly focuses on populations disproportionately affected by HIV or at elevated risk of acquisition, reflecting equity-centered priorities.
17) Which priority populations are specifically called out?
The NOFO calls out the following priority populations for the enhanced telehealth model:
- Cisgender Black women with HIV
- Transgender women
- Gay, bisexual, and other men who have sex with men (MSM)
18) What does the equity emphasis imply for program design?
Applicants should be prepared to design and evaluate telehealth strategies that are responsive to real-world barriers these groups may face, including access barriers, stigma, structural inequities, and challenges with continuity of care, while still producing measurable adherence, retention, and implementation outcomes.
19) Who is eligible to apply?
Eligible applicants are broad and include:
- State, county, and city governments
- Public and private institutions of higher education
- Federally recognized tribal governments and other tribal organizations
- Public housing authorities
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations, including small businesses
20) What is the maximum award amount (award ceiling)?
The award ceiling is $450,000.
21) How many awards did the CDC anticipate making?
The CDC anticipated making two awards.
22) When was the NOFO created?
The NOFO was created on January 10, 2023.
23) What was the application deadline?
The application deadline was March 17, 2023, with applications due by 11:59 pm ET.
24) How competitive is this opportunity likely to be?
Based on the limited number of anticipated awards (two) and the expectation of rigorous evaluation design, implementation planning, and required economic evaluation, the opportunity appears competitive.
25) What kinds of deliverables or results would an ideal project produce under this NOFO?
An ideal project would generate practical, actionable evidence on how enhanced telehealth models can keep people adherent to ART and PrEP and retained in care. It would also document real-world conditions needed for successful adoption, including implementation challenges and enablers, and produce cost and cost-effectiveness findings to inform sustainable deployment of telehealth enhancements in health systems and public health programs.
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