Opportunity Information: Apply for RFA PS 23 002
The grant opportunity titled "Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)" (Funding Opportunity Number RFA PS 23 002) is a Centers for Disease Control and Prevention (CDC) cooperative agreement designed to strengthen evidence around telehealth-based HIV care and prevention. The core aim is to evaluate an enhanced telehealth program that supports people in staying engaged in care and consistently taking HIV-related medications, while also examining how practical it is to integrate these telehealth strategies into routine clinical workflows over time. In other words, the project is not only about whether telehealth works, but also about what it takes to make it work reliably in real-world healthcare settings.
The program places strong emphasis on a hybrid effectiveness-implementation research approach, meaning the awardee is expected to study clinical outcomes and real-world delivery factors at the same time. On the effectiveness side, the work focuses on two related groups: clinically stable people with HIV who are on antiretroviral therapy (ART), and people at risk for HIV infection who are using pre-exposure prophylaxis (PrEP). For people with HIV, the intent is to determine whether an enhanced telehealth model helps maintain medication adherence and ongoing engagement in care. For PrEP users, the intent is to assess whether telehealth helps support adherence to PrEP as a prevention tool. On the implementation side, the awardee must identify barriers and facilitators that affect delivery, such as staffing, patient experience, technology access, clinical processes, and other operational issues that determine whether the approach can be sustained and scaled.
A major required component is an economic evaluation. The recipient is expected to assess the costs and cost-effectiveness of delivering telehealth services for patients using ART or PrEP. This includes looking beyond basic program expenses and considering whether the enhanced telehealth model provides good value relative to outcomes such as improved adherence, better retention in care, or more consistent use of prevention medication. The funding description also highlights specific telehealth enhancements that can be evaluated, which may include multi-month prescription refills to reduce pharmacy and clinic visit burden, biospecimen self-collection to support remote monitoring or laboratory needs, and the use of specialized staff roles such as community health workers and patient navigators to help patients overcome logistical, social, or system-level barriers.
The opportunity is explicitly focused on populations disproportionately affected by HIV or at elevated risk of acquisition, reflecting equity-centered public health priorities. The NOFO calls out cisgender Black women with HIV, transgender women, and gay, bisexual, and other men who have sex with men (MSM) as priority populations for the enhanced telehealth model. This emphasis signals that applicants should be prepared to design and evaluate telehealth strategies that are responsive to the realities these groups face, including access barriers, stigma, structural inequities, and challenges with continuity of care, while still producing measurable adherence, retention, and implementation outcomes.
Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism, which typically means the CDC expects substantial involvement during the project period (for example, collaboration on evaluation approaches, performance monitoring, or dissemination). The Assistance Listing (CFDA) number is 93.084, and eligible applicants are broad, spanning state, county, and city governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofit organizations (with or without 501(c)(3) status); and for-profit organizations, including small businesses. The NOFO was created on January 10, 2023, with an application deadline of March 17, 2023 (applications due by 11:59 pm ET). The award ceiling is $450,000, and the CDC anticipated making two awards, indicating a competitive process with limited slots and a clear expectation of rigorous evaluation design and strong implementation planning.
Taken together, the grant supports projects that can generate practical, actionable evidence on how enhanced telehealth models can keep people adherent to ART and PrEP and retained in care, while also documenting the real-world conditions needed for successful adoption. The ideal project under this NOFO would show measurable adherence and retention outcomes, provide a clear picture of implementation challenges and enablers, and produce cost and cost-effectiveness findings that help health systems and public health programs decide how to deploy telehealth enhancements in a sustainable way, especially for communities most impacted by HIV.Apply for RFA PS 23 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Jan 10, 2023.
- Applicants must submit their applications by Mar 17, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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