Natural Products NMR Open Data Exchange (NP-NODE) (U24 Clinical Trial Not Allowed) | RFA AT 19 002

Opportunity Information: Apply for RFA AT 19 002

The Natural Products NMR Open Data Exchange (NP-NODE) funding opportunity (RFA AT 19 002) is a National Institutes of Health (NIH) cooperative agreement (U24; clinical trial not allowed) led by the National Center for Complementary and Integrative Health (NCCIH) in partnership with the Office of Dietary Supplements (ODS). The central aim is to build a community-facing, standards-driven data infrastructure that makes raw nuclear magnetic resonance (NMR) data for natural products far easier to share, find, and reuse across the broader research ecosystem. Rather than supporting a single research project, the award is designed to create a widely used resource that enables coordination, harmonization, and efficient data exchange for natural products chemistry and related biology.

At the core of the award is the creation of an NMR Open Data Exchange, essentially a repository and associated toolset that can handle the practical realities of raw NMR data. The NP-NODE is expected to provide the capacity to upload and download datasets, store them securely and durably, and support searching and analysis of raw files. A key requirement is adherence to FAIR data principles: data should be Findable, Accessible, Interoperable, and Reusable. In real terms, this means the resource should support strong metadata and indexing so that datasets can be discovered, have clear access and reuse conditions, use standardized formats and vocabularies so data can be combined across labs and instruments, and provide enough context and provenance so other researchers can confidently reanalyze or repurpose the data. The longer-term promise of the initiative is to give natural products researchers the ability to mine NMR data at scale in ways that are difficult or impossible when data remain siloed in individual laboratories, supplemental files, or proprietary formats.

The opportunity also emphasizes community coordination and consensus-building, not just software development. Applicants are expected to run a deliberate outreach and engagement effort to gather input from diverse groups of natural products researchers and stakeholders. The goal is to develop agreement on repository features, data and metadata standards, and the most critical functions needed for adoption by the field. Beyond NMR-specific needs, the funding announcement explicitly calls for broader coordination across the natural products research community to accelerate the development of standards that improve sharing of data relevant to natural product chemistry and biology. In other words, the NP-NODE is meant to act as a hub that helps the field converge on common practices that make cross-study comparisons and large-scale analyses feasible.

Another important component is an advisory role tied to NCCIH policy. The NP-NODE awardee is expected to help NCCIH and ODS grantees comply with the NCCIH Product Integrity Policy, which generally focuses on ensuring that natural products used in NCCIH-supported research are well characterized, authentic, and of consistent quality. By supporting better data capture and exchange around characterization (including NMR evidence), the NP-NODE can make it easier for funded investigators to meet integrity and documentation expectations and for the community to evaluate and reproduce findings involving complex natural product materials.

Administratively, this is a discretionary health funding opportunity using a cooperative agreement mechanism, which typically implies substantial programmatic involvement by NIH staff compared with a standard research project grant. The listed award ceiling is $900,000, and the original closing date shown is 2019-04-01, indicating this specific announcement was time-bound to that application cycle. Two CFDA numbers are associated with the program: 93.213 and 93.321.

Eligibility is broad across many U.S.-based organization types, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other categories. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions. Foreign institutions (non-domestic, non-U.S. entities) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible. However, foreign components as defined in the NIH Grants Policy Statement are allowed, meaning a U.S. applicant may include certain foreign elements in the project when justified and consistent with NIH policy, even though a foreign institution cannot be the applicant organization.

Overall, the NP-NODE opportunity is best understood as an investment in shared scientific infrastructure for natural products research: a FAIR-aligned, raw-data-capable NMR exchange paired with community-led standards development and coordination, and with an added function of helping align grantee practices with NCCIH product integrity expectations. The intended outcome is a step-change in how natural products NMR data are preserved, discovered, combined, and analyzed across the field.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Natural Products NMR Open Data Exchange (NP-NODE) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.321.
• This funding opportunity was created on 2019-01-22.
• Applicants must submit their applications by 2019-04-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $900,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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