Opportunity Information: Apply for RFA TR 20 002

The Limited Competition: Microphysiological Systems Database Center (MPS DC) (U24 Clinical Trials Not Allowed) funding opportunity (RFA-TR-20-002) is a National Institutes of Health cooperative agreement designed to continue supporting the existing, currently funded MPS Database Center that serves the NIH Tissue Chip Consortium. It is a limited competition, meaning it is not broadly open to new applicants; it specifically invites an application from the current awardee operating the MPS DC. The program sits within the Department of Health and Human Services and is tied to CFDA 93.350, with the activity category listed as Health.

The central purpose of the award is to keep the MPS DC functioning as the consortium-wide hub for tissue chip information. In practical terms, the NIH expects the Center to integrate and coordinate data-related efforts across all funded Tissue Chip Consortium components and to operate as a community resource where tissue chip data and supporting materials can be deposited, curated, and accessed. This includes not only raw and processed datasets, but also standards, protocols, analytical tools, and other resources that help different groups generate comparable results and make meaningful use of each other’s outputs. The Center is positioned as a “clearinghouse,” so a major emphasis is on organizing and managing data in a way that improves findability, interoperability, and reuse across many different tissue chip models and research contexts.

A key expectation is modernization and expansion of data capabilities over time. The MPS DC is expected to incorporate novel approaches and technologies for data management and to enable more advanced uses of the accumulated information, including data mining and meta-analyses. The FOA highlights the need to support sharing and analysis across a wide range of variables: multiple organs and tissues, diverse diseases, many data types, and different tissue chip platforms. This points to a programmatic priority on cross-platform comparison and aggregation, rather than siloed datasets that only make sense within a single lab or device type.

Another major requirement is flexible access that serves multiple audiences while protecting sensitive or controlled information. The MPS DC is expected to provide different levels of public and tiered access to tissue chip information, recognizing that the user community ranges from basic and clinical researchers to academic and practicing physicians, as well as stakeholders like the pharmaceutical industry and government agencies such as NIH and FDA. The FOA also explicitly includes patients and the general public as intended audiences, which implies that the Center’s outputs should not only be technically robust but also presented in ways that can be navigated by non-specialists when appropriate. Tiered access suggests the Center must balance openness with security, compliance, and any data-use constraints.

The FOA also places special emphasis on coordination with the IQ Consortium, with the goal of building and offering a secure and customizable coordinated data management system. This system is intended to support the collection, storage, and analysis of diverse datasets produced by multiple tissue chip platforms, particularly in contexts relevant to drug development such as drug screening and safety and efficacy testing. That focus signals the NIH’s interest in ensuring that tissue chip outputs can be translated into evidence streams that are credible and usable for decision-making in drug discovery and regulatory science, not just exploratory academic research.

Finally, the application must include a clear plan to transition the MPS DC to full independence and self-sustainability before NIH support ends. This is a defining feature of the opportunity: applicants are expected to describe how the Center will maintain operations, continue serving the community, and fund ongoing infrastructure and curation without relying indefinitely on NIH dollars. In other words, beyond technical excellence, the proposal needs a credible long-term business and governance strategy that keeps the database center viable and useful after the award period.

Administratively, this opportunity uses the U24 cooperative agreement mechanism, which typically means substantial NIH programmatic involvement during the project compared with a standard grant. Clinical trials are not allowed under this FOA. The eligible applicant type listed is public and state-controlled institutions of higher education. The award ceiling is $1,500,000, and NIH anticipated making a single award. The FOA was created January 17, 2020, with an original closing date of March 13, 2020.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Microphysiological Systems Database Center (MPS DC) (U24 Clinical Trials Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350.
  • This funding opportunity was created on Jan 17, 2020.
  • Applicants must submit their applications by Mar 13, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Public and State controlled institutions of higher education.
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