Opportunity Information: Apply for RFA DA 25 072
Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-DA-25-072; CFDA 93.279) focused on improving how health systems and community providers deliver care to people affected by HIV and substance use disorders. The central aim is to fund research that tests enhanced, real-world models of care that more effectively integrate HIV services, addiction treatment, and primary care into cohesive, patient-centered approaches. The emphasis on an R01 mechanism signals a substantial, hypothesis-driven research project, and the “Clinical Trial required” designation means applicants are expected to conduct a clinical trial as part of the proposed work rather than only observational or implementation planning activities.
At its core, this notice of funding opportunity is about evaluating new or improved integrated service delivery models that can reduce HIV transmission, improve HIV outcomes (such as viral suppression and consistent engagement in care), and address addiction-related needs (such as initiation and retention in evidence-based treatment) while also meeting broader primary care needs. The integration theme implies approaches that reduce fragmentation across traditionally separate systems, for example by coordinating screening, diagnosis, treatment, follow-up, and supportive services in ways that are easier to access and more continuous for patients. In practical terms, projects supported under this NOFO would typically test specific strategies for “how care is organized and delivered,” such as co-locating services, strengthening care coordination, integrating medication treatment for substance use disorders into HIV or primary care settings, embedding HIV prevention or treatment services into addiction programs, or using team-based and/or technology-enabled workflows to keep patients engaged across all needed services.
The opportunity is open to a broad set of applicants across public, private, nonprofit, academic, and community sectors, reflecting the reality that effective HIV and addiction care often requires partnerships beyond a single clinic or institution. Eligible applicants explicitly include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations other than small businesses; small businesses; and “other” entities. The NOFO also highlights additional eligible applicant types, including faith-based or community-based organizations; eligible federal agencies; Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Indian/Native American Tribal Governments that are not federally recognized; regional organizations; U.S. territories or possessions; and even non-domestic (non-U.S.) entities/foreign organizations. This broad eligibility is important because it encourages proposals led by organizations that directly serve communities heavily impacted by HIV and substance use, including institutions with strong community trust and access to priority populations.
From a timing standpoint, the opportunity was created on 2024-10-15 and lists an original closing date of 2025-03-19. The notice provides an award ceiling field but it is not specified in the provided source data, and the expected number of awards is also not listed here. The activity categories associated with the announcement are health and education, which is consistent with NIH’s interest in service delivery research that can improve health outcomes while also generating generalizable knowledge about effective integrated care models.
Overall, this NOFO is positioned for teams that can design and run a rigorous clinical trial to test an integrated care model that links HIV services, addiction treatment, and primary care in a way that is scalable and sustainable in real practice settings. Competitive projects are likely to be those that address known barriers such as fragmented care pathways, stigma, limited access to medication treatment for substance use disorders, gaps in prevention and treatment continuity, and challenges in retaining patients in long-term HIV and addiction care. The intent is not simply to provide services, but to generate strong evidence about which integrated models work best, for whom, and under what conditions, in support of national goals to end the HIV epidemic while also addressing addiction as a major driver of preventable illness and inequity.Apply for RFA DA 25 072
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2024-10-15.
- Applicants must submit their applications by 2025-03-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required)."
What agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is RFA-DA-25-072.
What is the CFDA (Assistance Listing) number associated with this opportunity?
The CFDA/Assistance Listing number provided is 93.279.
What is the main purpose of this NOFO?
The central purpose is to fund research that tests enhanced, real-world models of care that integrate HIV services, addiction treatment, and primary care into cohesive, patient-centered approaches, with the goal of improving outcomes and reducing fragmentation across systems.
What kind of research does this opportunity support?
It supports hypothesis-driven research projects under an R01 mechanism that evaluate new or improved integrated service delivery models for people affected by HIV and substance use disorders, specifically in real-world care settings.
Is a clinical trial required?
Yes. The announcement is designated "Clinical Trial required," meaning applicants are expected to conduct a clinical trial as part of the proposed work rather than submitting only observational studies or implementation planning activities.
What does the R01 mechanism imply about the size or scope of the project?
The R01 mechanism signals a substantial research project intended to test clear hypotheses and produce generalizable evidence about integrated care models.
What outcomes is the NOFO trying to improve?
The NOFO emphasizes outcomes such as reducing HIV transmission, improving HIV outcomes (including viral suppression and consistent engagement in care), addressing addiction-related needs (including initiation and retention in evidence-based treatment), and meeting broader primary care needs.
What does "integrated" care mean in this context?
Integration refers to reducing fragmentation across traditionally separate systems by coordinating screening, diagnosis, treatment, follow-up, and supportive services so care is easier to access and more continuous for patients across HIV services, addiction treatment, and primary care.
What types of integrated service delivery models might be tested under this program?
Examples described include co-locating services, strengthening care coordination, integrating medication treatment for substance use disorders into HIV or primary care settings, embedding HIV prevention or treatment services into addiction programs, and using team-based and/or technology-enabled workflows to keep patients engaged across needed services.
Is this funding meant to support direct service provision only?
No. The intent is not simply to provide services, but to generate strong evidence through a clinical trial about which integrated models work best, for whom, and under what conditions, in support of ending the HIV epidemic while addressing addiction.
Who is eligible to apply?
The opportunity is open to a broad range of applicants across public, private, nonprofit, academic, and community sectors, including governments, higher education institutions, nonprofits (with or without 501(c)(3) status if not an institution of higher education), for-profits (including small businesses and other than small businesses), and other entities.
Are state, county, or city governments eligible?
Yes. Eligible applicants explicitly include state, county, city, or township governments, as well as special district governments.
Are colleges and universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible even if they do not have 501(c)(3) status?
Yes. Nonprofit organizations with or without 501(c)(3) status are listed as eligible, as long as they are not institutions of higher education.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also eligible.
Are federally recognized tribal governments eligible?
Yes. Federally recognized Native American tribal governments are eligible.
Are tribal organizations that are not federally recognized eligible?
Yes. Tribal organizations that are not federally recognized tribal governments are included in the listed eligible applicant types.
Are faith-based and community-based organizations eligible?
Yes. The NOFO highlights faith-based or community-based organizations as additional eligible applicant types.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are listed among the additional eligible applicant types.
Are non-U.S. (foreign) organizations eligible?
Yes. The NOFO indicates that non-domestic (non-U.S.) entities/foreign organizations are eligible.
Are specific institution types (HBCUs, HSIs, TCCUs, AANAPISIs) called out as eligible?
Yes. The NOFO highlights eligibility for Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Does the NOFO encourage partnerships?
Yes. The broad eligibility across sectors reflects that effective HIV and addiction care often requires partnerships beyond a single clinic or institution, including community providers and organizations with direct access to impacted populations.
When was this opportunity created?
The opportunity was created on 2024-10-15.
What is the original closing date?
The original closing date listed is 2025-03-19.
Is the award ceiling provided?
An award ceiling field is referenced, but the ceiling amount is not specified in the information provided.
How many awards are expected?
The expected number of awards is not listed in the information provided.
What activity categories are associated with this opportunity?
The activity categories associated with the announcement are health and education.
What kinds of barriers or challenges are projects expected to address?
The NOFO points to challenges such as fragmented care pathways, stigma, limited access to medication treatment for substance use disorders, gaps in prevention and treatment continuity, and difficulties retaining patients in long-term HIV and addiction care.
What is the broader public health goal behind this NOFO?
The broader goal is to support national efforts to end the HIV epidemic by producing evidence on integrated care approaches that improve HIV and addiction outcomes and can be scalable and sustainable in real practice settings.
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