Opportunity Information: Apply for PAR 24 276
The NIH National Center for Complementary and Integrative Health (NCCIH) is offering a cooperative agreement (U24) opportunity for a Data Coordinating Center (DCC) that will partner with an investigator-initiated, multi-site clinical trial of mind and body interventions. This DCC grant is not a standalone award; it must be submitted as a companion application that is tightly linked to a corresponding Clinical Coordinating Center (CCC) application proposing the actual Phase III (or later) multi-site trial under the companion funding announcement (PAR-21-243). NCCIH is essentially asking for a specialized coordinating hub that can run the trial infrastructure: central coordination across sites, administrative operations, data systems, and biostatistical leadership. Both the DCC and CCC applications have to be submitted at the same time for NCCIH to consider them together, and the DCC plan must be tailored specifically to the design and needs of the companion CCC-led trial.
The core purpose of the DCC is to provide comprehensive trial coordination and technical support so the multi-site study can be executed consistently, efficiently, and with high data quality. The NOFO emphasizes overall project coordination, administrative support, data management, and biostatistical support. In practical terms, that typically means building and maintaining the study database and data capture workflows, setting up standardized data definitions and procedures used across all clinical sites, overseeing data quality control and monitoring, producing interim reports and final analyses, supporting randomization and statistical analysis planning, and helping the CCC keep the trial on schedule and compliant with applicable policies. Because this is a cooperative agreement, the NIH expects substantial involvement from NCCIH staff during the life of the award, which usually translates into closer interaction, more structured oversight, and active collaboration than what is common under standard research project grants.
The trial supported by the paired CCC/DCC applications must align with NCCIHs mission and be considered a high priority by the Center. Applicants are directed to NCCIHs website for the Centers strategic vision and research priorities, and they are encouraged to contact the relevant scientific or research program official before submitting. That pre-submission contact is important here because NCCIH is signaling that program fit and priority will matter, and because the DCC application is inseparable from the underlying clinical trial proposal. If the clinical question, intervention, or target population is not a strong match for NCCIH, the paired applications are less likely to be competitive regardless of how strong the coordinating center plan may be.
A major compliance requirement in this NOFO is the Plan for Enhancing Diverse Perspectives (PEDP). The PEDP is not optional: it will be evaluated during peer review as part of the scientific and technical assessment, and applications that do not include a PEDP will be considered incomplete and withdrawn without review. In other words, the application package must clearly explain how diverse perspectives will be meaningfully incorporated into the project. Applicants are urged to study the PEDP instructions and NCCIH/NIH guidance closely and to treat it as an integral part of the submission rather than an add-on.
Eligibility is broad and includes many common applicant types such as state, county, and local governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; independent school districts; special district governments; public housing authorities; and federally recognized tribal governments and other eligible tribal organizations. The NOFO also calls out additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Asian American and Native American Pacific Islander serving institutions (AANAPISI), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, foreign organizations are explicitly not eligible to apply, and non-domestic components of U.S. organizations are also not eligible under this announcement.
Administratively, this opportunity is listed as PAR-24-276, a discretionary funding opportunity using the cooperative agreement funding instrument type, within the health activity category (CFDA 93.213). The original closing date provided is July 14, 2026. The notice does not provide an award ceiling or expected number of awards in the supplied listing, so applicants generally need to consult the full NOFO text for budget guidance, project period expectations, and any limits or special review considerations. The key takeaway is that NCCIH is seeking a well-integrated DCC partner for a high-priority, investigator-initiated, Phase III or later multi-site mind and body intervention trial, with strong infrastructure plans for coordination, data and statistical leadership, and a required, reviewable strategy for enhancing diverse perspectives.Apply for PAR 24 276
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Data Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative U24 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
- This funding opportunity was created on 2024-10-15.
- Applicants must submit their applications by 2026-07-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this NIH/NCCIH funding opportunity?
This opportunity (PAR-24-276) is a cooperative agreement (U24) from the NIH National Center for Complementary and Integrative Health (NCCIH) to support a Data Coordinating Center (DCC) for an investigator-initiated, multi-site clinical trial of mind and body interventions.
What is being funded: a clinical trial or a coordinating center?
This announcement funds the Data Coordinating Center (DCC), which provides trial-wide coordination infrastructure (for example: data systems, data management, and biostatistical support). The actual Phase III (or later) multi-site clinical trial is proposed under the companion Clinical Coordinating Center (CCC) funding announcement (PAR-21-243).
Is the DCC award a standalone grant?
No. The DCC application is not a standalone award. It must be submitted as a companion application that is tightly linked to a corresponding Clinical Coordinating Center (CCC) application proposing the Phase III (or later) multi-site trial under PAR-21-243.
What does it mean that the DCC application must be "tightly linked" to the CCC application?
It means the DCC plan must be tailored to the specific design and needs of the companion CCC-led clinical trial. NCCIH will consider the DCC and CCC applications together as a paired set, rather than as independent proposals.
Do the DCC and CCC applications need to be submitted at the same time?
Yes. Both applications have to be submitted at the same time for NCCIH to consider them together.
What is the role of the Data Coordinating Center (DCC) in this program?
The DCC serves as a specialized coordinating hub that supports consistent, efficient execution of the multi-site trial and promotes high data quality. The NOFO emphasizes overall project coordination, administrative support, data management, and biostatistical support.
What kinds of activities are typically included in a DCC scope of work under this NOFO?
Based on the description provided, typical DCC responsibilities include central coordination across sites, administrative operations, building and maintaining study databases and data capture workflows, establishing standardized data definitions and procedures used across all clinical sites, overseeing data quality control and monitoring, producing interim reports and final analyses, supporting randomization and statistical analysis planning, and helping the CCC keep the trial on schedule and compliant with applicable policies.
What type of award mechanism is this?
This is a cooperative agreement (U24). Under a cooperative agreement, NIH/NCCIH staff are expected to have substantial involvement during the award, which generally implies closer interaction, structured oversight, and active collaboration compared with standard research project grants.
What kind of clinical trial must the paired CCC/DCC applications support?
The paired applications must support an investigator-initiated, Phase III (or later) multi-site clinical trial focused on mind and body interventions, and the trial must align with NCCIH's mission and be considered a high priority by the Center.
How important is alignment with NCCIH mission and priorities?
Program fit is emphasized as important. The trial supported by the paired applications must align with NCCIH's mission and be considered a high priority by NCCIH. Applicants are directed to consult NCCIH strategic vision and research priorities and are encouraged to contact the relevant scientific or research program official before submitting.
Is pre-submission contact with NCCIH recommended?
Yes. Applicants are encouraged to contact the relevant scientific or research program official before submitting. This is highlighted as important because program fit and priority are expected to matter, and because the DCC application is inseparable from the underlying clinical trial proposal.
What is the Plan for Enhancing Diverse Perspectives (PEDP), and is it required?
The PEDP is a required element of the application. It will be evaluated during peer review as part of the scientific and technical assessment.
What happens if an application does not include a PEDP?
If a PEDP is not included, the application will be considered incomplete and withdrawn without review.
How should applicants treat the PEDP in preparing their application?
The PEDP should be treated as an integral part of the submission rather than an add-on. Applicants are urged to review PEDP instructions and NCCIH/NIH guidance closely and clearly explain how diverse perspectives will be meaningfully incorporated into the project.
Who is eligible to apply?
Eligibility is broad and includes state, county, and local governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; independent school districts; special district governments; public housing authorities; federally recognized tribal governments and other eligible tribal organizations; and additional eligible categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, AANAPISI institutions, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. Foreign organizations are explicitly not eligible to apply under this announcement.
Are non-domestic components of U.S. organizations allowed?
No. Non-domestic components of U.S. organizations are also not eligible under this announcement.
What is the activity category and CFDA listing for this opportunity?
The opportunity is within the health activity category and is listed under CFDA 93.213.
What is the opportunity number and what is the companion trial NOFO?
The DCC opportunity is PAR-24-276. The companion funding announcement for the Clinical Coordinating Center (CCC) proposing the Phase III (or later) trial is PAR-21-243.
What is the stated application due date?
The original closing date provided in the listing is July 14, 2026.
Does the provided listing include an award ceiling or the expected number of awards?
No. The supplied listing does not provide an award ceiling or an expected number of awards, so applicants are generally expected to consult the full NOFO text for budget guidance, project period expectations, and any limits or special review considerations.
What is NCCIH primarily looking for in the DCC partner?
NCCIH is seeking a well-integrated DCC partner for a high-priority, investigator-initiated, Phase III (or later) multi-site mind and body intervention trial, with strong plans for central coordination, administrative operations, data management infrastructure, and biostatistical leadership, and with a required PEDP that will be reviewed.
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