Data Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative U24 Clinical Trial Required) | PAR 24 276

Opportunity Information: Apply for PAR 24 276

The NIH National Center for Complementary and Integrative Health (NCCIH) is offering a cooperative agreement (U24) opportunity for a Data Coordinating Center (DCC) that will partner with an investigator-initiated, multi-site clinical trial of mind and body interventions. This DCC grant is not a standalone award; it must be submitted as a companion application that is tightly linked to a corresponding Clinical Coordinating Center (CCC) application proposing the actual Phase III (or later) multi-site trial under the companion funding announcement (PAR-21-243). NCCIH is essentially asking for a specialized coordinating hub that can run the trial infrastructure: central coordination across sites, administrative operations, data systems, and biostatistical leadership. Both the DCC and CCC applications have to be submitted at the same time for NCCIH to consider them together, and the DCC plan must be tailored specifically to the design and needs of the companion CCC-led trial.

The core purpose of the DCC is to provide comprehensive trial coordination and technical support so the multi-site study can be executed consistently, efficiently, and with high data quality. The NOFO emphasizes overall project coordination, administrative support, data management, and biostatistical support. In practical terms, that typically means building and maintaining the study database and data capture workflows, setting up standardized data definitions and procedures used across all clinical sites, overseeing data quality control and monitoring, producing interim reports and final analyses, supporting randomization and statistical analysis planning, and helping the CCC keep the trial on schedule and compliant with applicable policies. Because this is a cooperative agreement, the NIH expects substantial involvement from NCCIH staff during the life of the award, which usually translates into closer interaction, more structured oversight, and active collaboration than what is common under standard research project grants.

The trial supported by the paired CCC/DCC applications must align with NCCIHs mission and be considered a high priority by the Center. Applicants are directed to NCCIHs website for the Centers strategic vision and research priorities, and they are encouraged to contact the relevant scientific or research program official before submitting. That pre-submission contact is important here because NCCIH is signaling that program fit and priority will matter, and because the DCC application is inseparable from the underlying clinical trial proposal. If the clinical question, intervention, or target population is not a strong match for NCCIH, the paired applications are less likely to be competitive regardless of how strong the coordinating center plan may be.

A major compliance requirement in this NOFO is the Plan for Enhancing Diverse Perspectives (PEDP). The PEDP is not optional: it will be evaluated during peer review as part of the scientific and technical assessment, and applications that do not include a PEDP will be considered incomplete and withdrawn without review. In other words, the application package must clearly explain how diverse perspectives will be meaningfully incorporated into the project. Applicants are urged to study the PEDP instructions and NCCIH/NIH guidance closely and to treat it as an integral part of the submission rather than an add-on.

Eligibility is broad and includes many common applicant types such as state, county, and local governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; independent school districts; special district governments; public housing authorities; and federally recognized tribal governments and other eligible tribal organizations. The NOFO also calls out additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Asian American and Native American Pacific Islander serving institutions (AANAPISI), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, foreign organizations are explicitly not eligible to apply, and non-domestic components of U.S. organizations are also not eligible under this announcement.

Administratively, this opportunity is listed as PAR-24-276, a discretionary funding opportunity using the cooperative agreement funding instrument type, within the health activity category (CFDA 93.213). The original closing date provided is July 14, 2026. The notice does not provide an award ceiling or expected number of awards in the supplied listing, so applicants generally need to consult the full NOFO text for budget guidance, project period expectations, and any limits or special review considerations. The key takeaway is that NCCIH is seeking a well-integrated DCC partner for a high-priority, investigator-initiated, Phase III or later multi-site mind and body intervention trial, with strong infrastructure plans for coordination, data and statistical leadership, and a required, reviewable strategy for enhancing diverse perspectives.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Data Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative U24 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
• This funding opportunity was created on 2024-10-15.
• Applicants must submit their applications by 2026-07-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 24 276

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