Alzheimer's Disease Outcomes Research Resource (U2C) | RFA AG 17 052

Opportunity Information: Apply for RFA AG 17 052

The Alzheimer's Disease Outcomes Research Resource (U2C) funding opportunity (RFA-AG-17-052) is a National Institutes of Health (NIH) cooperative agreement designed to build a shared research resource focused on improving how researchers measure and track functional changes related to Alzheimer's disease. The core purpose is to establish the measurement properties (how well the measures perform, how reliable and valid they are, and how sensitive they are to change) of the NIH Toolbox for Assessment of Behavioral and Neurological Function when used with two key populations: (1) people with amnestic mild cognitive impairment (aMCI) and early Alzheimer's disease (AD), and (2) adults over 85 years old. By doing this, NIH aims to strengthen the field's ability to detect disease at the earliest stages, measure changes in function over time, and evaluate whether prevention strategies or treatments are working.

This FOA sits in the health research category (CFDA 93.866) and uses a cooperative agreement mechanism, meaning NIH expects an active partnership role rather than simply providing funds and stepping back. The single expected award signals that NIH was looking for one coordinated effort capable of producing standardized, widely usable evidence about how the NIH Toolbox performs in these older and cognitively impaired groups. In practical terms, the funded project would be expected to generate data and guidance that other investigators can rely on when selecting outcome measures for studies and clinical trials in early AD and in the oldest-old, where measurement challenges are common.

Eligibility is broad and includes many types of U.S.-based organizations and government entities. Applicants could include state, county, city, township, and special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and eligible federal agencies, as well as U.S. territories or possessions. While non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply as applicants, foreign components (as NIH defines them in its policy statement) are allowed, which typically means a U.S. applicant may include certain international elements in the project when justified and permitted by NIH rules.

Key administrative details in the source listing include an original closing date of February 2, 2017, and a creation date of November 23, 2016. The award ceiling is not specified in the provided excerpt. Overall, the opportunity is best understood as an infrastructure-and-methods investment: it is meant to produce robust, well-characterized outcome measurement tools for early Alzheimer's disease research and for studies involving very old adults, helping the broader research community compare results across studies and more confidently interpret changes in cognition and function over time.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimer's Disease Outcomes Research Resource (U2C)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2016-11-23.
• Applicants must submit their applications by 2017-02-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AG 17 052

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: