Opportunity Information: Apply for RFA AG 17 052
The Alzheimer's Disease Outcomes Research Resource (U2C) funding opportunity (RFA-AG-17-052) is a National Institutes of Health (NIH) cooperative agreement designed to build a shared research resource focused on improving how researchers measure and track functional changes related to Alzheimer's disease. The core purpose is to establish the measurement properties (how well the measures perform, how reliable and valid they are, and how sensitive they are to change) of the NIH Toolbox for Assessment of Behavioral and Neurological Function when used with two key populations: (1) people with amnestic mild cognitive impairment (aMCI) and early Alzheimer's disease (AD), and (2) adults over 85 years old. By doing this, NIH aims to strengthen the field's ability to detect disease at the earliest stages, measure changes in function over time, and evaluate whether prevention strategies or treatments are working.
This FOA sits in the health research category (CFDA 93.866) and uses a cooperative agreement mechanism, meaning NIH expects an active partnership role rather than simply providing funds and stepping back. The single expected award signals that NIH was looking for one coordinated effort capable of producing standardized, widely usable evidence about how the NIH Toolbox performs in these older and cognitively impaired groups. In practical terms, the funded project would be expected to generate data and guidance that other investigators can rely on when selecting outcome measures for studies and clinical trials in early AD and in the oldest-old, where measurement challenges are common.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. Applicants could include state, county, city, township, and special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and eligible federal agencies, as well as U.S. territories or possessions. While non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply as applicants, foreign components (as NIH defines them in its policy statement) are allowed, which typically means a U.S. applicant may include certain international elements in the project when justified and permitted by NIH rules.
Key administrative details in the source listing include an original closing date of February 2, 2017, and a creation date of November 23, 2016. The award ceiling is not specified in the provided excerpt. Overall, the opportunity is best understood as an infrastructure-and-methods investment: it is meant to produce robust, well-characterized outcome measurement tools for early Alzheimer's disease research and for studies involving very old adults, helping the broader research community compare results across studies and more confidently interpret changes in cognition and function over time.Apply for RFA AG 17 052
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimer's Disease Outcomes Research Resource (U2C)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2016-11-23.
- Applicants must submit their applications by 2017-02-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Alzheimer's Disease Outcomes Research Resource (U2C) funding opportunity?
It is a National Institutes of Health (NIH) cooperative agreement funding opportunity (RFA-AG-17-052) intended to build a shared research resource that improves how researchers measure and track functional changes related to Alzheimer's disease.
What is the main purpose of this funding opportunity?
The core purpose is to establish the measurement properties of the NIH Toolbox for Assessment of Behavioral and Neurological Function in specific populations, so researchers have stronger evidence on how well these measures work, how consistent they are, and how well they detect change over time.
What does NIH mean by "measurement properties" in this opportunity?
In this context, measurement properties refer to how well the NIH Toolbox measures perform, including reliability and validity, and how sensitive they are to detecting change (for example, whether they can pick up meaningful functional changes as Alzheimer's progresses or as people age).
Which assessment tool is the focus of the project?
The project focuses on the NIH Toolbox for Assessment of Behavioral and Neurological Function.
Which populations must the NIH Toolbox be evaluated in under this program?
The funding opportunity targets two key groups: (1) people with amnestic mild cognitive impairment (aMCI) and early Alzheimer's disease (AD), and (2) adults over 85 years old.
Why is NIH emphasizing early Alzheimer's disease and adults over 85?
These groups can present measurement challenges, and stronger evidence about outcome measures in these populations is intended to help the field detect disease earlier, measure functional change over time, and evaluate whether prevention strategies or treatments are working.
What type of funding mechanism is used (grant vs. cooperative agreement)?
This opportunity uses a cooperative agreement mechanism (U2C), which indicates NIH expects an active partnership role during the project rather than providing funding without ongoing involvement.
What does an NIH cooperative agreement imply for the relationship with NIH?
It implies NIH anticipates being actively involved as a partner. The opportunity is structured for collaboration and coordination, not a hands-off funding approach.
How many awards were expected under this opportunity?
The listing indicates a single expected award, suggesting NIH was seeking one coordinated effort to produce standardized, widely usable evidence about how the NIH Toolbox performs in the target groups.
What kinds of outputs would the funded project be expected to produce?
Based on the description, the project would be expected to generate data and guidance that other investigators can use when selecting outcome measures for studies and clinical trials in early Alzheimer's disease and in very old adults.
How would this resource help the broader research community?
The overall aim is to strengthen the ability to compare results across studies and to interpret changes in cognition and function more confidently over time, by producing robust, well-characterized outcome measurement evidence.
What is the CFDA number and general research category for this opportunity?
The opportunity is in the health research category and is associated with CFDA 93.866.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and government entities, such as state, county, city, township, and special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses.
Are institutions serving specific communities explicitly included as eligible applicants?
Yes. The announcement highlights additional eligible categories including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations.
Are regional organizations and federal agencies eligible?
Yes. The eligibility list includes regional organizations and eligible federal agencies.
Are U.S. territories or possessions eligible to apply?
Yes. The opportunity includes U.S. territories or possessions among eligible applicant types.
Can non-U.S. entities apply as the applicant organization?
No. Non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply as applicants.
Are foreign components allowed at all?
Yes. Foreign components (as NIH defines them in its policy statement) are allowed, meaning a U.S. applicant may include certain international elements in the project when justified and permitted by NIH rules.
What were the key dates listed for this opportunity?
The source listing includes a creation date of November 23, 2016, and an original closing date of February 2, 2017.
Is the maximum award amount (award ceiling) specified in the provided information?
No. The award ceiling is not specified in the provided excerpt.
How should this opportunity be understood in terms of what it funds?
It is best understood as an infrastructure-and-methods investment intended to produce standardized evidence about outcome measurement tools for early Alzheimer's disease research and for studies involving adults over 85.
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