Opportunity Information: Apply for RFA CA 18 023
This grant opportunity, titled "Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCI's Provocative Questions (P01 Clinical Trial Optional)" (Funding Opportunity Number RFA-CA-18-023), is a National Institutes of Health (NIH) discretionary grant announcement from the National Cancer Institute (NCI). It is designed specifically for investigators who already hold an active NCI-funded P01 (Program Project) award and want to submit a revision application that adds new work to their existing program. In other words, it is not a call for brand-new P01 programs; it is a mechanism to expand or extend the scope of an ongoing, funded P01 by adding new, clearly defined research aims.
The central purpose of the FOA is to bring additional P01-supported research effort to one of the NCI's "Provocative Questions" (PQs). The revision must focus on research tied to one of the 12 PQs that were published for new applications under two related NCI announcements: RFA-CA-18-019 (R01) and RFA-CA-18-020 (R21). The intent is to stimulate research that tackles important, challenging, and often under-addressed questions in cancer research. The FOA also signals that NCI is interested not only in projects that directly answer a PQ, but also in work that helps validate outcomes from PQ-driven research, or that supports adoption and dissemination of PQ research results in ways that could meaningfully influence cancer research practices and clinical care.
A key structural requirement is that the proposed studies in the revision must map to additional specific aims that expand the scope of an individual, already funded project within the parent P01. This means the new work should be integrated into the existing P01 structure rather than standing alone as an unrelated add-on. The revision is expected to extend what is already underway by adding new aims that are clearly justified, feasible, and aligned with the PQ focus. The announcement also notes that clinical trials are optional, meaning applicants may propose clinical trial-related work if it fits the PQ and the parent award's overall scientific direction, but a clinical trial is not required to be responsive.
In terms of who can apply, eligibility is broad across U.S.-based organizations typically allowed to receive NIH grants, as long as they are tied to an active NCI P01 award. Eligible applicants include state and county governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including those with or without 501(c)(3) status, as applicable); for-profit organizations (other than small businesses); small businesses; and other eligible entities listed in the source data. The FOA also explicitly highlights several institution types as eligible, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), reflecting NIH's general emphasis on broad institutional participation.
There are clear restrictions on non-U.S. participation at the applicant level. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined by the NIH Grants Policy Statement, which generally means parts of a project may be conducted outside the U.S. under specific conditions and with appropriate justification and compliance, even though the applicant organization itself must be U.S.-based.
The grant area falls under education and health, and it is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, 93.399), which correspond to different NCI program authorities and funding lines. The opportunity was created on 2018-04-03 and listed an original closing date of 2018-10-30. The award ceiling shown in the source information is $150,000, indicating the revision funding is capped at that level under this announcement. The record also lists "ExpectedAwards" without a specific number, implying the quantity of awards was not fixed in the summarized source data and could depend on application volume, responsiveness, and available funds.
Finally, the announcement notes that required registrations apply, which is standard for NIH opportunities and typically involves ensuring the applicant organization and key personnel have the appropriate federal and NIH systems registrations in place before submission. Overall, this FOA is best understood as a targeted add-on funding pathway for existing NCI P01 teams to incorporate new PQ-aligned aims into a currently funded program project, with the broader goal of accelerating progress on high-impact, carefully framed scientific questions in cancer research and, where relevant, improving the translation of those findings into clinical care.Apply for RFA CA 18 023
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCIs Provocative Questions (P01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on 2018-04-03.
- Applicants must submit their applications by 2018-10-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is an NIH discretionary grant announcement from the National Cancer Institute (NCI) titled "Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCI's Provocative Questions (P01 Clinical Trial Optional)." The Funding Opportunity Number (FOA) is RFA-CA-18-023.
What type of application is being requested?
The FOA requests revision applications to existing, active NCI-funded P01 (Program Project) awards. It is meant to add new work to an already funded P01 program, not to start a new P01.
Is this opportunity for brand-new P01 programs?
No. This is not a solicitation for new P01 applications. It is specifically for investigators with an active NCI-supported P01 who want to expand the scope of that ongoing award through a revision.
What is the main purpose of the revision?
The central purpose is to bring additional P01-supported research effort to one of the NCI's "Provocative Questions" (PQs) by adding new, clearly defined research aims to an existing P01.
What are the "Provocative Questions" (PQs) referenced in this FOA?
The revision must focus on research tied to one of 12 PQs that were published for new applications under related NCI announcements RFA-CA-18-019 (R01) and RFA-CA-18-020 (R21).
Does the revision have to directly answer one of the Provocative Questions?
The FOA indicates interest in projects that directly address a PQ, as well as work that helps validate outcomes from PQ-driven research or supports adoption and dissemination of PQ research results in ways that could influence cancer research practices and clinical care.
How must the new work fit into the existing P01?
The proposed studies must map to additional specific aims that expand the scope of an individual, already funded project within the parent P01. The new work should be integrated into the existing P01 structure rather than included as an unrelated add-on.
Can the revision propose a clinical trial?
Yes. Clinical trials are optional under this FOA. Applicants may propose clinical trial-related work if it fits the Provocative Question focus and aligns with the parent P01's overall scientific direction, but a clinical trial is not required.
Who is eligible to apply?
Eligibility is limited to U.S.-based organizations tied to an active NCI-funded P01 award. The FOA lists multiple eligible applicant types commonly allowed for NIH grants, including state and county governments, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations, for-profit organizations (other than small businesses), small businesses, and other eligible entities listed in the source information.
Are minority-serving institutions eligible?
Yes. The FOA explicitly highlights eligibility for several institution types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can a non-U.S. (foreign) institution apply as the applicant organization?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization.
Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are "foreign components" allowed at all?
Yes. The FOA notes that "foreign components" are allowed as defined by the NIH Grants Policy Statement. This generally means certain parts of a project may be conducted outside the U.S. under specific conditions and with appropriate justification and compliance, while the applicant organization itself must be U.S.-based.
What is the maximum award amount (award ceiling) for this revision?
The award ceiling shown in the source information is $150,000, indicating the revision funding is capped at that level under this announcement.
How many awards are expected?
The source information lists "ExpectedAwards" without a specific number. This suggests the number of awards was not fixed in the summarized data and may depend on factors such as application volume, responsiveness, and available funds.
What is the program area or subject matter of this grant?
The grant area is associated with education and health, and it is focused on cancer research through the National Cancer Institute.
Which CFDA numbers are associated with this opportunity?
This opportunity is associated with multiple CFDA numbers: 93.393, 93.394, 93.395, 93.396, and 93.399.
When was this opportunity created and what was the listed closing date?
The opportunity was created on 2018-04-03 and listed an original closing date of 2018-10-30.
What registrations are required?
The announcement notes that required registrations apply, which is standard for NIH opportunities. Applicants should ensure the applicant organization and key personnel have the appropriate federal and NIH systems registrations in place before submission.
In plain terms, what is this FOA best suited for?
This FOA is best understood as a targeted add-on funding pathway for existing NCI P01 teams to incorporate new Provocative Question-aligned aims into a currently funded program project, with the broader goal of accelerating progress on high-impact cancer research questions and, where relevant, improving translation into clinical care.
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