Opportunity Information: Apply for RFA DE 19 003
This funding opportunity (RFA-DE-19-003) is a limited competition renewal for the FaceBase 3 Data Management and Integration Hub, a central resource supported by the National Institute of Dental and Craniofacial Research (NIDCR) within NIH. FaceBase (www.facebase.org) functions as a data repository and knowledgebase designed to speed progress in craniofacial research by assembling, organizing, and sharing high-value datasets and related tools focused on craniofacial development and craniofacial dysmorphologies. The Hub is essentially the backbone of the FaceBase program, making sure that data produced across the program can be curated properly, connected to other relevant datasets, and delivered to researchers in a way that is searchable, usable, and scientifically meaningful.
The core purpose of the award is to continue and expand the Hub responsibilities that have existed since FaceBase began. That includes collecting datasets and analytic tools produced by FaceBase dataset-generating "spoke" projects, performing curation and quality control, integrating those resources into coherent data structures, and disseminating them broadly through the FaceBase website. In practical terms, the Hub is expected to maintain and improve the repository infrastructure, ensure consistent metadata and standards so datasets can be compared and combined, and provide user-facing functionality that helps researchers find what they need and understand how to use it. A major emphasis is placed on integration and presentation of existing FaceBase datasets, along with ongoing development or adoption of improved approaches for data search, browsing, and visualization so the platform remains modern and useful as data types and community needs evolve.
FaceBase 3 also adds an important new mission beyond simply managing datasets generated by FaceBase spokes. The Hub is expected to actively work with investigators across the broader craniofacial research community to bring external datasets into FaceBase. That means helping researchers make their data compatible with FaceBase data models, guiding them on formatting and metadata expectations, and then curating and integrating those new datasets alongside existing FaceBase holdings. This expansion is meant to increase the reach and impact of FaceBase by turning it into a more comprehensive community repository, not just a home for data created within the immediate FaceBase program. The goal is to improve interoperability and reuse, so that studies from different labs, methods, and model systems can be connected and analyzed together.
The mechanism is a U01 cooperative agreement, which typically implies substantial involvement from NIH staff in coordinating activities, setting expectations, and ensuring the Hub aligns with program-wide goals. The notice specifies "Clinical Trial Not Allowed," so the work is focused on data infrastructure, curation, integration, and community enablement rather than running clinical intervention studies. The activity category is health, and the CFDA number is 93.121. Eligibility is limited to public and state-controlled institutions of higher education, reflecting the infrastructure-heavy, long-term stewardship role expected of the awardee. The opportunity was created February 14, 2018, with an original closing date of July 17, 2018.
Financially, the posting indicates an award ceiling of $1,900,000 and an expectation of one award, underscoring that this is a single-hub model where one lead institution is responsible for the platform and its services. Overall, the grant is aimed at ensuring continuity of FaceBase as a reliable, accessible, and evolving national resource for craniofacial data, while also broadening its scope by onboarding and harmonizing datasets from the wider research community so that FaceBase can serve as a central, integrative knowledgebase for the field.Apply for RFA DE 19 003
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: FaceBase 3: Craniofacial Development and Dysmorphology Data Management and Integration Hub (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on Feb 14, 2018.
- Applicants must submit their applications by Jul 17, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,900,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity (RFA-DE-19-003) is a limited competition renewal to support the FaceBase 3 Data Management and Integration Hub, a central resource within the NIH-supported FaceBase program.
Which agency and institute are supporting this award?
The Hub is supported by the National Institute of Dental and Craniofacial Research (NIDCR) within the National Institutes of Health (NIH).
What is FaceBase?
FaceBase (www.facebase.org) is a data repository and knowledgebase designed to accelerate craniofacial research by assembling, organizing, and sharing high-value datasets and related tools focused on craniofacial development and craniofacial dysmorphologies.
What is the FaceBase 3 Data Management and Integration Hub?
The Hub is the backbone of the FaceBase program. It is responsible for ensuring that data produced across FaceBase can be curated appropriately, connected to other relevant datasets, and delivered through the FaceBase website in a searchable, usable, and scientifically meaningful way.
What is the core purpose of the award?
The award is intended to continue and expand the Hub responsibilities that have existed since FaceBase began, focusing on data collection, curation, quality control, integration, and dissemination through the FaceBase platform.
What types of resources does the Hub manage?
The Hub manages datasets and analytic tools produced by FaceBase dataset-generating "spoke" projects, and it is also expected to bring external craniofacial research datasets into FaceBase as part of FaceBase 3.
What does "spoke" mean in the FaceBase program context?
"Spoke" projects refer to FaceBase dataset-generating projects that produce datasets and analytic tools that are then collected, curated, integrated, and disseminated by the Hub.
What are the Hub's main responsibilities?
The Hub is expected to (1) collect datasets and analytic tools from FaceBase spokes, (2) perform curation and quality control, (3) integrate resources into coherent data structures, and (4) disseminate them broadly through the FaceBase website.
What is meant by data curation and quality control in this opportunity?
Within the context provided, data curation and quality control refer to preparing datasets so they are properly organized, consistently described, and suitable for integration and reuse, including ensuring they can be delivered to researchers in a usable and scientifically meaningful form.
What does "integration" mean for the Hub?
Integration involves connecting datasets and tools into coherent data structures so they can be compared, combined, and explored across studies, including linking to other relevant datasets and presenting the results in ways that support scientific use.
What is expected regarding the FaceBase repository infrastructure?
The Hub is expected to maintain and improve the repository infrastructure and ensure that FaceBase remains a reliable platform for storing, organizing, and sharing craniofacial research datasets and tools.
Why are metadata and standards emphasized?
Consistent metadata and standards are emphasized so datasets can be compared and combined, improving interoperability and reuse across different labs, methods, and model systems.
What user-facing features are expected from the Hub?
The Hub is expected to provide functionality that helps researchers find relevant datasets and tools and understand how to use them, including improved approaches for data search, browsing, and visualization.
Is the Hub expected to modernize the platform over time?
Yes. A major emphasis is on ongoing development or adoption of improved approaches for data search, browsing, and visualization so the platform remains modern and useful as data types and community needs evolve.
What is new in FaceBase 3 compared to prior phases?
FaceBase 3 adds a new mission for the Hub: actively working with the broader craniofacial research community to bring external datasets into FaceBase, not only managing data produced by FaceBase spokes.
What does onboarding external datasets involve?
It involves helping external investigators make their data compatible with FaceBase data models, guiding them on formatting and metadata expectations, and then curating and integrating those datasets alongside existing FaceBase holdings.
What is the overall goal of bringing in external datasets?
The goal is to broaden FaceBase into a more comprehensive community repository and improve interoperability and reuse so studies from different labs, methods, and model systems can be connected and analyzed together.
What is the funding mechanism for this opportunity?
The mechanism is a U01 cooperative agreement.
What does a U01 cooperative agreement imply for how the project is run?
As described, a U01 cooperative agreement typically implies substantial involvement from NIH staff in coordinating activities, setting expectations, and ensuring the Hub aligns with program-wide goals.
Are clinical trials allowed under this opportunity?
No. The opportunity specifies "Clinical Trial Not Allowed."
If clinical trials are not allowed, what is the work focused on?
The work is focused on data infrastructure, curation, integration, dissemination, and enabling the research community through improved access and interoperability, rather than conducting clinical intervention studies.
What is the activity category?
The activity category listed is health.
What is the CFDA number for this opportunity?
The CFDA number is 93.121.
Who is eligible to apply?
Eligibility is limited to public and state-controlled institutions of higher education.
Why is eligibility limited to public and state-controlled institutions of higher education?
The description frames the Hub as an infrastructure-heavy, long-term stewardship role, and the opportunity explicitly limits eligibility to those institution types.
Is this a limited competition?
Yes. The opportunity is described as a limited competition renewal for the FaceBase 3 Data Management and Integration Hub.
How many awards are expected?
The posting indicates an expectation of one award, reflecting a single-hub model with one lead institution responsible for the platform and its services.
What is the award ceiling?
The award ceiling listed is $1,900,000.
When was this opportunity created and when did it originally close?
The opportunity was created on February 14, 2018, with an original closing date of July 17, 2018.
What is the intended impact of this grant?
The grant aims to ensure continuity of FaceBase as a reliable, accessible, and evolving national resource for craniofacial data, while expanding its scope by onboarding and harmonizing datasets from the wider research community.
How does this opportunity support craniofacial research?
It supports craniofacial research by ensuring high-value datasets and tools are assembled, curated, integrated, and shared through a central platform so researchers can search, access, compare, and reuse data more effectively.
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