Opportunity Information: Apply for PAR 23 163

The National Institutes of Health (NIH) grant opportunity PAR-23-163, titled "Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (T32 Clinical Trial Not Allowed)," supports institutional T32 training programs aimed at building the workforce needed to move Alzheimer’s and related dementias research from basic discovery toward therapies. This notice is a reissue of PAR-21-112, with an important administrative update: it explicitly adds the option to apply as a renewal (in addition to other allowed application types) in the relevant sections of the funding announcement. The overall focus remains the same, but the renewal option is meant to help successful programs continue and expand their training efforts.

The core purpose of this program is workforce development in translational AD/ADRD research, spanning the full pipeline from target discovery through clinical development. NIH is looking for programs that can prepare scientists to work across disciplines rather than staying in narrow silos. The emphasis is on cultivating a diverse and interdisciplinary pool of trainees who can connect basic biology to translational work and ultimately to clinically relevant outcomes. While the mechanism is a training grant (T32), the opportunity explicitly indicates "Clinical Trial Not Allowed," meaning the supported training activities should not include conducting independent clinical trials under this award, even though trainees may learn clinical research methods and work with clinical data or preclinical-to-clinical translation topics as part of their training.

The funded programs are expected to train both predoctoral and postdoctoral researchers and to recruit trainees with varied educational and technical backgrounds. The announcement highlights a mix of fields that the training should integrate, including basic biology and disease mechanisms, translational and clinical research concepts, data science approaches, behavioral research, and both traditional and emerging drug discovery and development disciplines. In practice, NIH is signaling that competitive programs will offer structured, cross-cutting curricula and mentored experiences that equip trainees to do rigorous, modern Alzheimer’s research, including skills like handling complex datasets, understanding disease pathways, designing translational studies, and navigating the steps that connect laboratory findings to therapeutic development.

Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants listed include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement at the applicant/component level: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible.

From an administrative standpoint, this is a discretionary grant in the health category (CFDA 93.866) offered by NIH. The record shows an original closing date of 2023-09-25 and a creation date of 2023-04-11. Award ceiling and expected number of awards are not specified in the provided listing, which typically means applicants should consult the full announcement text for budget structure, trainee slot guidance, allowable costs, and institute-specific priorities. Overall, the opportunity is designed to help institutions build durable, interdisciplinary training environments that can consistently produce researchers capable of advancing translational Alzheimer’s and ADRD science in a way that is methodologically strong, team-oriented, and responsive to the complexity of these diseases.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (T32 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
  • This funding opportunity was created on 2023-04-11.
  • Applicants must submit their applications by 2023-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PAR 23 163

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